Dexibuprofen

Description

Dexibuprofen is a medicine known as a nonsteroidal anti-inflammatory drug. It is ibuprofen’s active dextrorotatory enantiomer. A racemic mixture of both isomers is present in the majority of ibuprofen formulations. If you have ever experienced an allergic reaction to any other anti-inflammatory painkiller, tell your doctor before taking dexibuprofen. It is normal to take either a few tablets every day – your primary care physician will let you know which of these is ideal for you. Consume the pills with food.

Anti-inflammatory painkillers like dexibuprofen are additionally called non-steroidal calming drugs (NSAIDs), or once in a while ‘hostile to inflammatories’. Dexibuprofen is recommended to treat difficult circumstances like joint inflammation, injuries and strains, period (feminine) agony, and dental agony. Dexibuprofen works by inhibiting the activity of your body’s naturally occurring cyclo-oxygenase (COX) enzymes. These enzymes in the body also make other chemicals called prostaglandins. A few prostaglandins are delivered at destinations of injury or harm and cause torment and irritation. When COX enzymes are blocked, prostaglandins are produced less, which reduces pain and inflammation.

• AHFS/Drugs.com: International Drug Names
• ATC code: M01AE14 (WHO)
• Routes of administration: Oral
• Generic Name – Dexibuprofen
• Type – Small Molecule
• Groups – Approved, Investigational
• Chemical Formula – C13H18O2

Synonyms

• d-ibuproten
• Dexibuprofen
• Dexibuprofeno

Associated Conditions

• Fever
• Inflammation
• Pain
• Spasms

Associated Therapies

• Analgesia

Background

Dexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID). It is a physicochemically distinct but pharmacologically effective enantiomer of racemic ibuprofen. Due to a higher concentration of the active S enantiomer, it is proposed to be more pharmacologically active, tolerable, and safe than ibuprofen. Dexibuprofen has a more slow disintegration rate in the mimicked gastric and intestinal juices contrasted and racemic ibuprofen and showcases worked on oral bioavailability. For Digestion, Compounds, Transporters, and Carriers Areas, allude to Ibuprofen.

Chemistry

A racemic ibuprofen chiral switch is dexibuprofen. According to the Cahn Ingold prelog rule, the chiral carbon in dexibuprofen is given the absolute configuration (S).

Pharmacology

Dexibuprofen is a racemic ibuprofen (NSAID) enantiomer that is used to treat pain and inflammation. It is a pharmacologically active enantiomer.

Ibuprofen is an α-aryl propionic corrosive, utilized to a great extent in the treatment of rheumatoid joint pain and generally involved non-prescription medication for migraines and minor torments. This medication has a chiral focus and exists as a couple of enantiomers. The desired therapeutic effect is brought about by the (S)-ibuprofen eutomer. The distomer, the inactive (R)-enantiomer, undergoes a unidirectional chiral inversion to produce the active (S)-enantiomer, which serves as a precursor to the active (S)-enantiomer. That is, the distomer is transformed into the eutomer in vivo when ibuprofen is administered as a racemate, but the latter is unaffected.

Mechanism of action

Like common nonsteroidal anti-inflammatory drugs (NSAIDs), dexibuprofen is an active enantiomer of ibuprofen that inhibits the COX-2 isoform of the arachidonic acid COX to suppress prostanoid synthesis in inflammatory cells.

Ibuprofen, a propionic corrosive non-steroidal anti-inflammatory drug (NSAID), is regarded as the first propionic. Ibuprofen was at last protected in 1961 and this medication was first sent off against rheumatoid joint pain in the UK in 1969 and USA in 1974. Ibuprofen is administered as a racemic mixture of the products currently on the market. It was the first over-the-counter NSAID available. The alpha-methyl acyl-CoA racemase’s activity causes the R-enantiomer to undergo extensive interconversion to the S-enantiomer in vivo following administration. Specifically, it is for the most part suggested that the S-enantiomer is fit for inspiring more grounded pharmacological movement than the R-enantiomer.

Absorption

• When 300mg of dexibuprofen is taken orally, it takes 2.25-5 hours for the plasma concentration to reach its peak.
• It is very much consumed orally and the pinnacle serum fixation can be achieved in 1 to 2 hours after extravascular organization. At the point when ibuprofen is directed following a feast there is a slight decrease in the retention rate yet there is no adjustment of the degree of retention.
• At the point when orally directed, the assimilation of ibuprofen in grown-ups is quickly finished in the upper GI lot. The Cmax, Tmax, and AUC typically range between 20 and 70 milligrams per milliliter. h/ml. The enantiomer form, route, and dosage of administration can all have an impact on these parameters.

The volume of distribution – The apparent magnitude of the distribution of ibuprofen is 0.1 L/kg.

Protein binding –  Ibuprofen dosage is more than 99 percent bound to plasma proteins and site II of purified albumin. At concentrations greater than 20 mcg/ml, binding appears to be saturable and becomes non-linear.

Metabolism

The major metabolites of ibuprofen, the hydroxylated and carboxylated derivatives, are rapidly metabolized and biotransformed in the liver. In vivo, the activity of alpha-methyl acyl-CoA racemase converts the R-enantiomer to the more active S-enantiomer immediately after it is absorbed (53 to 65 percent).

Stage I of ibuprofen digestion includes hydroxylation of the isobutyl chains to create 2-or 3-hydroxy subsidiaries, trailed by oxidation to 2-carboxy-ibuprofen and p-carboxy-2-propionate. The activities of the cytochrome P450 isoforms CYP 2C9, CYP 2C19, and CYP 2C8 carry out these oxidative reactions. As a result, these enzymes participate in the alkyl side chain oxidation process, producing hydroxyl and carboxyl derivatives. From these compounds, the significant impetus in the arrangement of oxidative metabolites is the isoform CYP 2C9.

The metabolic stage I is trailed by deliberately ease II in which the oxidative metabolites might be formed into glucuronide before discharge. Phenolic and acyl glucuronides are produced by this activity.

Route of elimination

Mostly renal discharge. Because it is quickly metabolized and excreted in the urine, ibuprofen makes up more than 90% of the dose that is given. It is gone within 24 hours of the last dose, and almost all of the dose that was given goes through metabolism or about 99 percent of the dose that is gone. Unchanged drug and active phase II metabolites account for 1% of the administered dose in the bile.

In conclusion, ibuprofen is eliminated as conjugates or metabolites. The end of ibuprofen isn’t impeded by advanced age or the presence of renal debilitation

Half-life – Dexibuprofen 300mg tablets taken orally last between 2.2 and 4.7 hours.

Pathways – Not Available

Pharmacogenomic Effects or ADRs – Not Available

Before taking Dexibuprofen

Some medications can’t be used by people with certain conditions, and others can only be used with extra caution. Your doctor needs to know the following before you begin taking dexibuprofen:

• If you have at any point had a hypersensitive response to some other NSAID (like ibuprofen, naproxen, diclofenac, and indomethacin), or some other medication.
• if you have ever experienced stomach or intestine bleeding, such as from a peptic or duodenal ulcer.
• if you suffer from asthma or any other allergy condition.
• If you have a heart condition or an issue with your veins or dissemination.
• if you are breastfeeding, attempting to conceive, and/or pregnant.
• On the off chance that you have at any point had blood-thickening issues.
• If you have a fiery entrail problem like Crohn’s illness or ulcerative colitis.
• Assuming that you have hypertension.
• if you have a disorder of the connective tissue, like systemic lupus erythematosus. This inflammatory condition is also known as SLE or lupus.
• if your kidneys or liver are functioning improperly.
• suppose there are any other drugs you are taking. This includes herbal and complementary medicines and medications that can be purchased without a prescription.

How to take Dexibuprofen

• Read the printed information leaflet that is included in the package from the manufacturer before beginning the treatment. It will provide you with additional information about dexibuprofen and a comprehensive list of the potential side effects of taking it.
• One 300 mg tablet will be prescribed for you to take twice or three times daily. The appropriate dosage for you will be determined by your physician. Take the medications exactly as prescribed by your physician.
• Taking dexibuprofen with food; the ideal time is during mealtime. Your stomach will be protected from side effects like indigestion and irritation from this. A great many people find it assists with gulping the tablet with a beverage of water.
• If you neglect to take a portion, accept it when you recall (except if it is almost time for your next portion, in which case take the following portion when it is expected and depart out the bypassed portion). To make up for a missed dose, do not take two doses at once.
• Dexibuprofen is a medicine known as a nonsteroidal anti-inflammatory drug. It is ibuprofen’s active dextrorotatory enantiomer. A racemic mixture of both isomers is present in the majority of ibuprofen formulations. If you have ever experienced an allergic reaction to any other anti-inflammatory painkiller, tell your medic before taking the dexibuprofen drug.

Getting the most from your treatment

• To lessen the likelihood of adverse effects, your doctor will try to give you the lowest possible dose for the shortest amount of time. Your doctor may want to prescribe another medication in addition to dexibuprofen if you need to take it for a long time to prevent stomach irritation.
• Try to go to your doctor’s appointments regularly. This is essential if you are taking dexibuprofen for a long-term condition so that your doctor can monitor your progress.
• Anti-inflammatory medications like dexibuprofen can exacerbate asthma symptoms like wheezing and shortness of breath. If this occurs to you, you should stop taking the tablets and see a doctor right away.
• Long-term users of some anti-inflammatory painkillers are known to have a slightly increased risk of heart and blood vessel issues. This will be explained to you by your doctor, who will then prescribe the lowest possible dose for the shortest amount of time to lower the risk. Limit your intake to the recommended level.
• On the off chance that you purchase any prescriptions, check with a drug specialist that they are protected to take with a mitigating like dexibuprofen. This is because you should not take these tablets with any other anti-inflammatory pain reliever, some of which are included in “over-the-counter” cold and flu remedies.
• Assuming that you are expected to have an activity or dental treatment, tell the individual completing the treatment which medications you are taking.

Can dexibuprofen cause problems?

Alongside their helpful impacts, most prescriptions can cause undesirable aftereffects albeit not every person encounters them. Some of the most common ones that are linked to dexibuprofen are listed in the table below. A comprehensive list of the potential side effects of your medication can be found in the printed information leaflet provided by the manufacturer. If any of the following symptoms persist or become problematic, consult your doctor or pharmacist.

• stomach pain, indigestion, and heartburn (also known as reflux). Always take your medication with a meal or a glass of milk. Assuming that the distress proceeds, talk with your primary care physician
• Looseness of the bowels – Drink a lot of water to supplant the lost liquids
• Feeling debilitated (queasiness) or being wiped out (retching) – Stick to basic dinners – keep away from greasy or fiery food sources
• Feeling dazed or tired – Don’t drive and don’t utilize devices or machines while impacted
• Skin rash – On the off chance that you foster a serious, irritated skin rash quit taking dexibuprofen and let your PCP in immediately

Important: if you experience any of the accompanying more uncommon however conceivably serious side effects, quit taking dexibuprofen and contact your primary care physician for counsel immediately:

• if you are having trouble breathing, such as being out of breath or wheezing.
• If you have any indications of an unfavorably susceptible response like expanding around your mouth or face, or a serious bothersome skin rash.
• If you have severe stomach (abdominal) pain, pass blood or black stools, or come up with blood.

Talk to your doctor or pharmacist for more information if you experience any other symptoms that you think are caused by the tablets.

How to store dexibuprofen

• Keep all medications out of the span and sight of kids.
• Store in a cool, dry spot, away from unaffected passion and light.

Important information about all medicines

• Never exceed the recommended dosage. Go to the emergency room of your local hospital if you think that you or someone else has taken too much of this medication. Take the receptacle with you actually if it is empty.
• This medication is for you. Regardless of whether their condition has all the earmarks of being like yours, you ought to never give it to any other person.
• Try not to keep obsolete or undesirable medications. They will be disposed of for you at your local pharmacy if you take them there.
• If you have any concerns about this medication, speak with your pharmacist.

What is the interaction of dexibuprofen?

A drug interaction can occur if you take more than one medication at the same time or combine it with certain foods or beverages.

Interaction with Medicine – Zydol 50Mg Suspension

Information About Dexibuproben

Non-steroidal anti-inflammatory drugs (NSAIDs) include dexibuprofen. The drug’s primary purpose is to alleviate pain, particularly in cases of severe arthritis, muscular strains, sprains, and other painful injuries. The medication may likewise be utilized to give help from feminine agony, stomach spasms, and, surprisingly, dental hurts. You can take it with food or as directed by your medic. Anti-inflammatory painkillers like dexibuprofen are additionally called non-steroidal calming drugs (NSAIDs), or once in a while ‘hostile to inflammatories’. Dexibuprofen is recommended to treat difficult circumstances like joint inflammation, injuries and strains, period (feminine) agony, and dental agony. Dexibuprofen works by inhibiting the activity of your body’s naturally occurring cyclo-oxygenase (COX) enzymes. These enzymes in the body also make other chemicals called prostaglandins. A few prostaglandins are delivered at destinations of injury or harm and cause torment and irritation. When COX enzymes are blocked, prostaglandins are produced less, which reduces pain and inflammation.

Similar to ibuprofen and other nonsteroidal anti-inflammatory drugs (NSAIDs), dexibuprofen prevents arachidonic acid oxidation by inhibiting the COX enzyme. This outcome is a decline in the development of prostaglandins which are liable for irritation and agony and hence prompt its pain relieving and mitigating properties. Unless necessary, you should not take this medication if you have Crohn’s disease, heart disease, peptic ulcers, gastrointestinal bleeding, or kidney or liver disease. It should be used with caution in people who are elderly, have high blood pressure, diabetes, or high cholesterol, and have had a stroke in the past.

Heartburn, indigestion, and other stomach irritations are the most common adverse effects of this medication. Therefore, it is suggested that it be taken with food to prevent this discomfort. It should not be taken before driving a vehicle or operating machinery because it also has the potential to cause dizziness, weakness, or drowsiness.

The data given here relies on the salt substance of the prescription. The medication may have different effects and uses for different people. Before using this medication, it is best to talk to an expert in internal medicine.

What are the side effects of dexibuprofen?

• Abdominal Pain
• Constipation
• Diarrhea
• Epigastric Pain
• Flatulence
• Nausea
• Vomiting
• Indigestion

Dexibuprofen Uses

Dexibuprofen is utilized for relief from discomfort. It reduces inflammation and pain in conditions like toothache, period pain, muscle pain, and joint pain.

How Dexibuprofen works

Non-steroidal anti-inflammatory drugs (NSAIDs) include dexibuprofen. It works by preventing certain chemical messengers, which are responsible for fever, pain, and inflammation (redness and swelling), from being released. Common side effects of Dexibuprofen are vomiting, Stomach torment, Sickness, Acid reflux, and Indigestion

Expert Advice for Dexibuprofen

• Dexibuprofen has been prescribed to you to alleviate pain and inflammation.
• Take it with food or milk to bypass stomach upset.
• Follow your physician’s education and take it as directed. Utilization for an extended period could result in serious side effects like bleeding from the stomach and problems with the kidneys.
• Try not to take acid reflux cures (stomach settling agents) something like two hours of taking Dexibuprofen.
• Drinking alcohol while taking Dexibuprofen can make you more likely to have stomach issues.
• If you have a history of heart condition or stroke, tell your doctor.
• Your PCP may invariably screen your kidney capability, liver capability, and levels of blood parts assuming that you are taking this treatment for long-haul treatment.

key highlights of dexibuprofen 

• Is it safe to drink?
• It is unknown how alcohol affects them. If it’s not too much trouble, suggest your medic
• Are there any pregnancy alerts?
• Sibet 300mg tablet might be hazardous to use during pregnancy.
• While a few human studies have been conducted, animal studies have demonstrated negative effects on the fetus. Despite the risk, the benefits of use during pregnancy may be acceptable. Confer your medic if it is not too much trouble.
• Are there any warnings about breastfeeding?
• Unknown. There are no studies on humans or animals. Please check with your physician.
• Is driving while taking this medication safe?
• Patients should avoid driving or operating machinery as they may experience dizziness, drowsiness, tiredness, or blurred vision.
• Is kidney function affected by this?
• There is a lack of data. Before taking the medication, please check with your doctor.
• Is liver function affected by this?
• There is a lack of data. Before taking the medication, please check with your doctor.

FAQ