Dexketoprofen

Description

Dexketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used for its analgesic (pain-relieving) and anti-inflammatory properties. It belongs to the propionic acid class of NSAIDs and is chemically similar to ketoprofen. Dexketoprofen is available in various formulations, including tablets, capsules, and topical gels.

Menarini produces it under the brand name Keral. It is available on prescription only in the UK as dexketoprofen trometamol, and Menarini’s Enantyum is sold in Latin America.

• Molar mass: 254.28 g/mol
• AHFS/Drugs.com: International Drug Names
• ATC code: M01AE17 (WHO) M02AA27 (WHO)
• Generic Name – Dexketoprofen
• Type – Small Molecule
• Groups – Approved, Investigational
• Chemical Formula – C16H14OF3

Synonyms

• Dexketoprofen
• Dexketoprofeno

Associated Conditions

• Ankylosing Spondylitis (AS)
• Extra-Articular Rheumatism
• Gouty Arthritis
• Inflammation
• Menstrual Distress (Dysmenorrhea)
• Musculoskeletal Pain
• Myalgia
• Osteoarthritis (OA)
• Pain
• Post Traumatic Pain
• Postoperative pain
• Renal Colic
• Rheumatoid Arthritis
• Muscle Spasms
• Spinal pain
• Inflammation localized
• Localized pain
• Mild to moderate pain

About Dexketoprofen

Non-steroidal anti-inflammatory medication is dexketoprofen. It is accessible in different nations in Europe, Asia, and Latin America. It has antipyretic, anti-inflammatory, and analgesic properties. DEXKETOPROFEN has a place with the gathering of meds called NSAIDs (Non-Steroidal Calming Medications) principally used to ease gentle to direct torment and irritation in conditions like outer muscle torment, difficult periods (dysmenorrhoea), toothache, and so forth. It is also used to alleviate surgery-related pain, headache-like migraines, and knee pain. The body experiences awkward uproars as a result of torture, which is a side effect caused by the sensory system. Inflammation, redness, swelling, and fever are all symptoms of pain.

DEXKETOPROFEN contains “Dexketoprofen,” which works by inhibiting the body’s cyclo-oxygenase (COX) enzymes, which are responsible for the production of another chemical called “prostaglandins.” Pain and swelling are brought on by the production of these prostaglandins at injury sites. By impeding the impact of COX catalysts, fewer PGs are delivered, which diminishes gentle to direct agony and irritation at the harmed or harmed site.

Follow your doctor’s instructions when taking DEXKETOPROFEN. Depending on your medical condition, you should take DEXKETOPROFEN for as long as your doctor has prescribed. Common side effects include indigestion, heartburn, nausea, vomiting, and stomach pain from time to time. The majority of these side effects would not need treatment and will go away on their own over time. However, if you persist to encounter these side effects, you should talk to your doctor.

To treat your condition strongly, keep taking DEXKETOPROFEN for however long your PCP has endorsed. To try not to repeat side effects, don’t stop it halfway. If you are pregnant or breastfeeding, talk to your doctor before taking DEXKETOPROFEN; your PCP will endorse DEXKETOPROFEN provided that the advantages offset the dangers. DEXKETOPROFEN ought not to be given to kids as well-being and adequacy have not been laid out. Dexketoprofen can make you drowsy and dizzy, so drive carefully. When taking DEXKETOPROFEN, alcohol should not be consumed because it can make you more drowsy and dizzy. It could also make stomach bleeding more likely. It ought a gone through ongoing and not be utilized by a patient’s heart sidestep a medical procedure or going to have it.

Mechanism of action

It is a non-steroidal anti-inflammatory drug (NSAID) that inhibits the cyclooxygenase pathway (both COX-1 and COX-2) to reduce prostaglandin synthesis.

Pharmacodynamics

This medication is an isomer of ketoprofen. An analgesic, anti-inflammatory, and antipyretic propionic acid derivative, dexketoprofen

Absorption

Within 30 minutes of taking Dexketoprofen by mouth, its effects kick in. Dexketoprofen has a plasma half-life of about four to six hours. About 30 minutes is the Cmax.

Volume of distribution = <0.25 L/kg 

Protein binding – Highly protein bound 

Metabolism

Dexketoprofen is exceptionally lipophilic and is processed in the liver by glucuronidation. In one study, young healthy adults received 25 mg of dexketoprofen orally for approximately 30 minutes, with a Cmax of 3.7 0.72 mg/l. The liver’s CYP2C8 and CYP2C9 cytochrome P450 enzymes break down dexketoprofen trometamol. Dexketoprofen trometamol has a few metabolites, with hydroxyl subordinates making up the best volume. Hydroxylation has a minor effect on humans. Dexketoprofen is essentially formed into an acyl-glucuronide

Route of elimination

Within the first twelve hours after ingestion, approximately 70 to 80 percent of the dose is recovered in the form of the acyl-conjugated form in the urine.

Half-life – 1.65 hf

Clearance – primarily unchanged, cleared primarily through glucuronide conjugation and renal excretion.

Toxicity

Nausea and/or vomiting, stomach pain, loose bowels, and stomach-related issues (dyspepsia) are the most widely recognized side effects of harmfulness. Dizziness, sleepiness, disturbed sleep, nervousness, headache, palpitations, flushing, stomach issues, constipation, dry mouth, flatulence, skin rash, fatigue, pain, feeling shivering and feverish, and malaise are additional symptoms of toxicity. Serious harmfulness can prompt thrombocytopenia and pallor with draining episodes. There is a slight increase in the risk of myocardial infarction with dexketoprofen.

Pathways – Not Available

Pharmacogenomic Effects/ADRs – Not Available

Before taking dexketoprofen

A few drugs are not reasonable for individuals with specific circumstances, and once in a while, medication must be utilized on the off chance that additional consideration is taken. Hence, before you begin taking dexketoprofen, your primary care physician should be aware:

• On the occasion that you have at any point had a stomach or duodenal ulcer, or on the other hand, assuming you have a provocative entrail issue like Crohn’s illness or ulcerative colitis.
• On the off chance that you have asthma or some other hypersensitive problem.
• On the off chance that you are pregnant, pursuing a child, or breastfeeding.
• if your kidneys and/or liver are functioning improperly.
• In the occurrence that you have a heart condition or an issue with your veins or course.
• Assuming that you have hypertension.
• if you have issues with blood clotting.
• if your blood sugar and/or cholesterol levels are high.
• if you have a circumstance of the connective tissue, like systemic lupus erythematosus. This inflammatory condition is also known as Systemic lupus erythematosus or lupus.
• if there are any other drugs or pills you are taking. This includes herbal and complementary medicines, as well as medications that can be purchased without a prescription.
• if you have ever been allergic to any other medication or an NSAID like aspirin, ibuprofen, diclofenac, or indomethacin.

How to take dexketoprofen

• Read the printed information leaflet provided by the manufacturer inside the pack before beginning to take dexketoprofen. It will give you more data about the tablets and will give you a full rundown of the incidental effects which you could insight from taking them.
• Your primary care physician will let you know the number of tablets to take and how frequently to take them, yet this will be something like three 25 mg tablets altogether every day. Contingent to your condition, you will be approached to take either a portion of a 25 mg tablet each 4 to 6 hours or one 25 mg tablet at regular intervals. You will be given a short course of treatment – you can quit taking the tablets once the torment has gone.
• Take the tablets with a beverage of water. They work faster if taken when the stomach is empty, so it’s best to take them about 30 minutes before eating. However, if taking the tablets makes you feel uneasy, it is best to take them with food to help alleviate any symptoms of sickness.
• In the possibility that you neglect to take a portion, accept it when you recall except if your next portion is expected. If your next dose is due, take the one that is due and skip the one you forgot. To make up for an ignored dose, do not take two doses at once.

Getting the most from your treatment

• Dexketoprofen will be prescribed to you at the lowest possible effective dose for the shortest amount of time. This is to lower the likelihood of adverse effects. Take the pills exactly as prescribed by your medic.
• Attempt to keep any subsequent meetings with your PCP. This is so that your doctor can see how you’re doing.
• Dexketoprofen can exacerbate asthmatic symptoms like wheezing and shortness of breath. In the possibility that this happens to you, you ought to quit taking the tablets and consider your primary care physician to be soon as could be expected.
• On the off chance that you purchase any prescriptions, check with a drug specialist that they are reasonable for you to take. This is due to the particular that dexketoprofen should not be taken with any other anti-inflammatory painkiller, some of which are included in “over-the-counter” cold and flu remedies.
• Assuming you are having an activity or dental treatment, tell the individual completing the treatment which prescriptions you are taking.

Can dexketoprofen cause problems?

The majority of medicines can have undesirable side effects in addition to their beneficial effects, though not everyone experiences them. The table beneath contains a portion of the more normal ones related to dexketoprofen. A thorough rundown of the likely symptoms of your medicine can be found in the printed data flyer given by the maker. On the other hand, an example data pamphlet from a maker can be found in the reference segment underneath. Consult your physician or pharmacist if any of the following symptoms persist or become problematic.

Important: if you experience any of the following infrequent but possibly serious symptoms, stop taking dexketoprofen and contact your doctor for recommendation straightaway:

• On the off chance that you have any breathing troubles, for example, wheezing or shortness of breath.
• In the event that you have any indications of an unfavorably susceptible response like enlarging around your mouth or face, or a bothersome skin rash.
• If you experience severe stomach pains, bloody stools, or black stools.

Talk to your doctor or pharmacist for additional guidance if you experience any additional symptoms that you believe are brought on by the medication.

How to store dexketoprofen

• Keep all drugs out of the reach and/or sight of youngsters.
• Store in a cool, dry location, away from direct heat and/or light.

When not to use it?

Allergy

Patients who are allergic to dexketoprofen, other non-steroidal anti-inflammatory medications, or any of the other inactive ingredients in this medication should not take it.

Bleeding disorder

Because it may exacerbate the patient’s condition, this medication is not recommended for use in patients with bleeding disorders or active bleeding.

Gastrointestinal disorders

Patients with gastrointestinal conditions like Crohn’s disease, ulcerative colitis, gastrointestinal bleeding, and others should not take this medication. since it might degenerate the patient’s disorder.

Severe heart failure

Due to the possibility that it will exacerbate the patient’s condition, this medication should not be administered to patients with severe heart failure.

Severe dehydration

Due to the increased risk of worsening the patient’s condition, this medication should not be used in patients with severe dehydration caused by vomiting, diarrhea, or insufficient fluid intake.

Skin disorders

Patients with skin conditions like eczema, acne, open wounds, skin lesions, dermatosis, etc. should not use this medication on their skin in its topical forms—gel and spray, because of the potential for side effects. because of the expanded gamble of serious unfavorable reactions.

Uses of Dexketoprofen

Musculoskeletal pain, Dysmenorrhea (period pain), and also Dental pain, etc.

Medicinal Benefits

Dexketoprofen in DEXKETOPROFEN works by inhibiting the body’s cyclo-oxygenase (COX) enzymes, which are responsible for the production of another chemical known as “prostaglandins” (PG). These prostaglandins are created at injury destinations and cause torment and expansion. By hindering the COX compound’s impact, lesser PGs are delivered, which decreases gently to direct agony and aggravation at the harmed or harmed site. In conditions such as muscle pain, dysmenorrhea (menstrual cramps), and dental pain, DEXKETOPROFEN is used to reduce pain and inflammation. Additionally, it assuages gentle to direct agony related to medical procedures, headaches, and knee torment.

Directions for Use

Take DEXKETOPROFEN with dinner, soon after a feast, or as exhorted by the specialist. Gulp down it as an entire with water; try not to smash, break or bite it.

Storage

Store in a relaxed and dry place away from sunlight

Side Effects of Dexketoprofen

• Vomiting
• Nausea
• Stomach pain
• Dizziness
• Headache
• Dry mouth
• Indigestion
• Heartburn
• Weakness

In-Depth Precautions and Warning

Drug Warnings

Prior to taking DEXKETOPROFEN, let your surgeon know if you have at any point been hypersensitive to some other NSAID or prescription, including anti-inflammatory medicine, ibuprofen, diclofenac, as well as indomethacin. If you have had a stomach or duodenal ulcer, an inflammatory bowel disease like Crohn’s disease or ulcerative colitis, asthma, liver or kidney problems, heart problems, high blood pressure, problems with blood clotting, high blood sugar or cholesterol levels, or lupus erythematosus, tell your doctor before taking DEXKETOPROFEN. 

DEXKETOPROFEN might cause an expanded gamble of serious heart issues like myocardial dead tissue and stroke, which can be lethal. The gamble might increment for delayed utilization of DEXKETOPROFEN. Patients who have recently had or are about to have heart bypass surgery should not use it. DEXKETOPROFEN raises the risk of fatal, severe gastrointestinal conditions like stomach or intestine perforation, ulceration, and bleeding. The doctor can reduce the dosage for elderly patients because they are more likely to have gastrointestinal bleeding issues. Pregnant or breastfeeding ladies are encouraged to counsel a specialist before taking DEXKETOPROFEN. DEXKETOPROFEN should not be given to children under the age of 18. Drinking alcohol while taking DEXKETOPROFEN can make you more drowsy and increase your risk of stomach bleeding. Fever and pain may be covered up by DEXKETOPROFEN when an infection is present. It might make it harder to treat infections like pneumonia and chickenpox-related bacterial skin infections, which could make complications worse.

Drug Interactions

Drug-Drug Interactions: DEXKETOPROFEN may also interact with medicines which utilize to treat pain (naproxen, aspirin), medicines used to prevent blood clots (warfarin, heparin, streptokinase), medicines utilized to feast certain mood disorders (lithium), medicines used for rheumatoid arthritis and cancer (methotrexate ), medicines utilized for epilepsy (hydantoins, phenytoin), antibiotics (sulphamethoxazole, ciprofloxacin, levofloxacin), medicines employed to treat chronic venous ulcers (pentoxifylline, oxpentifylline), medicines used to treat viral infections (zidovudine), anti-diabetics (chlorpropamide, glibenclamide), medicines employed to treat immune system diseases and in organ transplant (cyclosporine, tacrolimus), medicines used to treat depression (duloxetine, sertraline, escitalopram), medicines used to treat high blood pressure and fluid retention (fluoxetine), medicines utilized as an abortifacient (to terminate a pregnancy) (mifepristone).

Drug-Food Interactions: Try not to drink liquor alongside DEXKETOPROFEN as it could prompt expanded sluggishness and wooziness. It could also make stomach bleeding more likely.

Drug-Disease Interactions: Patients with ulcers or bleeding in the stomach or intestines, heart failure, fluid retention (edema), asthma, high blood pressure, hyperkalemia (high potassium levels), thrombosis (clot formation), anemia (low red blood cells), rash, platelet aggregation inhibition, and kidney and liver issues should not take DEXKETOPROFEN.

Drug-Drug Interactions Checker List:

• NAPROXEN
• ASPIRIN
• WARFARIN
• HEPARIN
• STREPTOKINASE
• LITHIUM
• SULPHAMETHOXAZOLE+TRIMETHOPRIM
• CIPROFLOXACIN
• LEVOFLOXACIN
• PENTOXIFYLLINE
• ZIDOVUDINE
• CHLORPROPAMIDE
• GLIBENCLAMIDE
• CYCLOSPORINE
• TACROLIMUS
• DULOXETINE
• SERTRALINE
• ESCITALOPRAM
• FLUOXETINE
• MIFEPRESTONE

Safety Advice

Alcohol

• UNSAFE
• You should avoid consuming alcohol while taking DEXKETOPROFEN. Liquor admission, alongside DEXKETOPROFEN, may cause expanded sleepiness and sluggishness and may increment gastrointestinal ulcer hazard and draining like different pain relievers.

Pregnancy

• CAUTION
• DEXKETOPROFEN is a Class B pregnancy drug. DEXKETOPROFEN should not be taken during pregnancy, especially in the last trimester. If it’s not too much trouble, counsel your PCP before taking DEXKETOPROFEN assuming you are pregnant, your primary care physician will endorse DEXKETOPROFEN on the off chance that the advantages offset the dangers.

Breastfeeding

• CAUTION
• It is not known whether DEXKETOPROFEN gives into the mother’s milk. If you are breastfeeding, please talk to your physician before taking DEXKETOPROFEN. Your medic will only give you DEXKETOPROFEN if the benefits outweigh the risks.

Driving

• CAUTION
• In some instances, DEXKETOPROFEN may cause drowsiness, dizziness, tiredness, and vision problems. So it is better not to drive a motor vehicle and/or use heavy machinery if you feel dizzy.

Liver

• CAUTION
• Be careful when taking DEXKETOPROFEN, especially if you have a history of liver conditions or diseases. The portion might be altered by your primary care medic as required.

Kidney

• CAUTION
• Dose adjustment may be needed and should be utilized with caution in patients with kidney impairment or kidney disorder. Please confer with your medic if you have kidney impairment or any concerns regarding this.

Children

• CAUTION
• DEXKETOPROFEN should not be utilized in children as efficacy and safety have not been established.

Habit Forming

No

Diet & Lifestyle Advice

• Moving your body strengthens your muscles and reduces joint stiffness. It would be helpful to engage in gentle activities like swimming or walking for 20 to 30 minutes.
• Performing yoga may likewise help in working on joint adaptability and torment the executives.
• Keep a solid load by performing standard low-strain activities and eating good food.
• Get satisfactory rest, as resting the muscles can help in lessening aggravation and expanding.
• Regularly apply a cold or hot compress to the joints and follow heat or cold therapy.
• Take a warm bubble bath, meditate, read a book, or listen to soothing music to relieve stress.
• Needle therapy, kneading, and active recuperation may likewise be useful.
• Eat food wealthy in cell reinforcements, for example, berries, spinach, kidney beans, dull chocolate, and so on.
• Flavonoids in foods help to reduce inflammation. Soy, berries, broccoli, grapes, and green tea are a few examples.
• Avoid drinking alcohol.

Special Advise

• If you are taking this medication for a long time, your doctor may keep an eye on your levels of blood components, kidney and liver function, and so on.
• Please tell your doctor if you are elderly, a smoker, have had a stroke in the past, or have high blood pressure, diabetes, or high cholesterol, as these conditions may make you more likely to have heart problems.

Dosage

Missed Dose

Spray, gel, and tablet: In the possibility that a portion of this medication is missed, take/utilize the portion when you recollect it. If the next dose is almost due, skip the missed one and use or take the next dose. To make up for the missed dose, do not crease the dose. Injection: Since this medication is directed in the medical clinic or clinical setting by certified medical care proficient, the probability of missing a portion is extremely low.

Overdose

Spray, gel, and tablet: In the event of an overdose, contact your doctor or get immediate medical attention. Injection: The risk of overdosing is very low because this medication is given by a trained medical professional in a hospital setting. Notwithstanding, crisis clinical treatment will be started by the specialist if excess is thought.

Expert Advice For Dexketoprofen

• You have been endorsed Dexketoprofen to alleviate agony and aggravation.
• Take it with food or milk to forestall a steamed stomach.
• Accept it according to the portion and term recommended by your physician. Long-haul use might prompt serious intricacies, for instance, stomach draining and/or kidney issues.
• Try not to take heartburn cures (stomach settling agents) for no less than two hours of taking Dexketoprofen.
• Abstain from drinking liquor while accepting Dexketoprofen as it can expand your gamble of stomach issues.
• Illuminate your medic on the off chance that you have a past filled with coronary illness or stroke.
• Your primary care physician may consistently screen your kidney capability, liver capability, and levels of blood parts in the circumstance that you are taking this medication for long-haul treatment.

FAQs

Author: Dr. Prachi Patel