Salsalate

Description

Salsalate is a drug in the class of nonsteroidal anti-inflammatory drugs and salicylates. Salsalate is the generic duration of a medicine pill vended beneath the trademark names Mono-Gesic, Salflex, Disalcid, and Salsitab. Other generic and brand-name formulations might be public.

• Molar mass: 258.23 g/mol
• AHFS/Drugs: Monograph
• ATC code: N02BA06 (WHO)
• Type – Small Molecule
• Groups – Approved
• Color: Yellow
• Shape: round
• Imprint: 809. This medicine is a yellow, rounded, film-coated, tablet impressed with “809”.

Synonyms

• Disalicylic acid
• Disalicylsäure
• O-Salicylcylsalicylsäure
• o-Salicylsalicylic acid
• Salicylic acid bimolecular ester
• Salicyloxysalicylic acid
• Salicyloylsalicylic acid
• Salicylsalicylic acid
• Salsalate
• Salsalato
• Salsalatum
• Sasapyrin
• Sasapyrine
• Sasapyrinum

Background

Salsalate is an oral non-steroidal anti-inflammatory medication. The inhibition of prostaglandin synthesis and release may account for the mode of action of salsalate as an anti-inflammatory and anti-rheumatic agent. It has been demonstrated that the active in vivo product of salsalate, salicylic acid, can be used to treat arthritic conditions. Contrary to aspirin, salsalate does not make feces or the gastrointestinal system lose more blood than a placebo.

In the small intestine, where it is partially hydrolyzed into two molecules of salicylic acid, salsalate is easily soluble. The body rapidly hydrolyzes the parent compound through esterase, absorbing a significant amount of it unchanged. The parent compound has an approximately one-hour elimination half-life. At salsalate’s anti-inflammatory doses, the biotransformation of salicylic acid, the active metabolite, is saturated. The salicylic acid half-life goes from 3.5 to 16 or more hours due to this capacity-limited biotransformation.

What is salsalate?

Salsalate, also known as salicylates (sa-LIS-il-ates), is a non-steroidal anti-inflammatory drug (NSAID). Salsalate is used to ease rheumatoid arthritis, osteoarthritis, or rheumatic disorders-related pain, swelling, and stiffness in the joints. Salsalate may also be used for objectives not listed in this prescription guide.

Mechanism of action

Analogous to other NSAIDs, salsalate has a wimpy inhibitory effect on the cyclooxygenase enzyme and reduces the production of several proinflammatory chemical cues such as interleukin-6, TNF-alpha, and C-reactive protein.

The mechanism via which salsalate is thought to facilitate the presentation of these inflammatory chemical signals is through the inhibition of IκB kinase resulting in decreased activity of NF-κB genes. This mechanism is thought to be accountable for salsalate’s insulin-sensitizing and blood sugar-lowering belongings.

The mode of anti-inflammatory action of salsalate and other nonsteroidal anti-inflammatory drugs is not fully defined but appears to be primarily associated with the inhibition of prostaglandin synthesis. This inhibition of prostaglandin synthesis is done through the inactivation of cyclooxygenase-1 (COX-1) and COX-2, which are responsible for catalyzing the formation of prostaglandins in the arachidonic acid pathway. Salsalate appears to selectively inhibit prostaglandin production in vivo, resulting in anti-inflammatory action comparable to aspirin and indomethacin, even though salicylic acid, the major metabolite of salsalate, is a poor inhibitor of prostaglandin synthesis in vitro. Unlike aspirin drug, salsalate does not inhibit platelet expansion.

Pharmacodynamics

Salsalate is a nonsteroidal calming specialist for the oral organization. The inhibition of prostaglandin synthesis and release may account for the mode of action of salsalate as an anti-inflammatory and anti-rheumatic agent. It has been demonstrated that the active in vivo product of salsalate, salicylic acid, can be used to treat arthritic conditions. Contrary to aspirin, salsalate does not make feces or the gastrointestinal system lose more blood than a placebo.

Absorption 

Salicylic acid is partially hydrolyzed into two molecules in the small intestine, but salsalate is insoluble in acidic gastric fluids (less than 0.1 mg/ml at pH 1.0). Unchanged, a significant amount of the parent compound is absorbed. When the two medications are administered as salicylic acid molar equivalents (3.6 g salsalate/5 g aspirin), the amount of salicylic acid that is available from salsalate is approximately 15% lower than the amount that is available from aspirin. Salicylate absorption is slowed by food, including salsalate.

The volume of distribution – Not Available

Protein binding

Salicylate: 90 to 95% bound at plasma salicylate concentrations <100 mcg/mL; 70 to 85% bound at concentrations of 100 to 400 mcg/mL; 25 to 60% bound at concentrations >400 mcg/mL.

Metabolism

Salsalate is promptly dissolvable in the small digestive system where it is somewhat hydrolyzed to two atoms of salicylic corrosive. The body rapidly hydrolyzes the parent compound through esterase, absorbing a significant amount of it unchanged.

Route of elimination – Not Available

Half-life

The parent compound has an end half-existence of around 60 minutes. At salsalate’s anti-inflammatory doses, the biotransformation of salicylic acid, the active metabolite, is saturated. The salicylic acid half-life goes from 3.5 to 16 or more hours due to this capacity-limited biotransformation.

Clearance – Not Available

Toxicity – Adults who consume 10 to 30 grams of salicylates have died, but people who consume much larger amounts have not died.

How should this medicine be used?

Salsalate is utilized to relieve pain from various diseases. It also relieves pain, swelling, and joint stiffness from arthritis. A nonsteroidal anti-inflammatory drug (NSAID) is the name given to this medication. Two to three times per day, take this medication by mouth with a full glass of water (8 ounces, or 240 milliliters), or as prescribed by your doctor. Try not to rest for no less than 10 minutes after taking this medication. Take this medication with food, milk, and/or an antacid if you encounter stomach upset.

The dosage is determined by your medical condition and response to therapy Take this medication at the lowest possible effective dose for the shortest amount of time to reduce your risk of stomach bleeding and other adverse effects. Do not take it for longer than prescribed, take it more frequently, or at a higher dose. Keep taking this medication as directed for ongoing conditions like arthritis. Talk to your apothecary or doctor about the risks and benefits.

For some disorders, like arthritis, regular use of this medication may take up to two weeks before you see full results. Keep in mind that painkillers are most effective when taken as soon as the first signs of pain appear if you are taking this medication “as needed” rather than regularly. The medication may not be as effective if you wait until the symptoms have gotten worse. If your symptoms persist or get worse, or if you experience new symptoms, inform your doctor.

Salsalate arrives as a pill to take by the jaw. It is usually taken two to three periods a day. To avoid an upset stomach, salsalate can also be taken with food or milk. Take salsalate at roughly the same times every day. Observe the directions on your medication label, and ask your doctor or pharmacist to elucidate any part you do not understand. Take salsalate exactly as directed. Do not take more profitable or more undersized of it or take it more often than prescribed by your doctor. The medication’s full effect may not be felt for three to four days. If your symptoms do not enhance or get worse, contact your medic. 

Why is this medication prescribed?

Salsalate is used to relieve pain, tenderness, swelling, and stiffness induced by rheumatoid arthritis (arthritis rendered by swelling of the lining of the joints), osteoarthritis (arthritis compelled by a breakdown of the lining of the joints), and other disorders that cause swelling. Salsalate is in a category of nonsteroidal anti-inflammatory medications (NSAIDs) called salicylates. It works by stopping the body’s presentation of a significance that causes pain, fever, and swelling.

How should I take salsalate?

Follow all of the directions on your prescription label and read all of the medication guides. Utilize the most minimal portion that is viable in treating your condition.

• You might not see the full consequences of taking a salsalate drug for up to four days. How long you will be treated with salsalate is up to your doctor.
• Certain medical tests may also be affected by this medication. Inform any medical professional who treats you of your use of salsalate.
• Be sure to tell your doctor or dentist if you need surgery, dental work, or any other medical procedure. You might have to halt for some time.
• If you use this medication long haul, you might require continuous clinical trials.
• Keep the supply away from heat and moisture at room temperature. When not useful, seal the bottle tightly.

Other uses for this drug  – This medication may be prescribed for additional advantages; For more information, consult your physician or pharmacist.

What should I avoid while taking salsalate?

• Avoid alcohol. Heavy drinking can improve your chance of stomach bleeding.
• Demand a surgeon as well as drug specialist prior to taking different meds that may likewise incorporate a salicylate (like ibuprofen, magnesium salicylate, choline salicylate, and furthermore diflunisal, Ecotrin, Tricosal, Trilisate, and others).
• Ask a doctor or pharmacist before utilizing other medicines for pain, fever, swelling, or cold and flu symptoms. They could likewise have components comparable to salsalate (like anti-inflammatory medicine, choline salicylate, as well as magnesium salicylate). Escape driving and/or hazardous activity until you understand how salsalate will affect you. Your reactions might also be impaired.
• If you are also taking low-dose aspirin to contain a heart attack or stroke, do not stop taking it or adjust your dose without your physician’s advice. Aspirin should be used for cardiovascular disorders only under the supervision of a physician.
• Dodge smoking, since it can also improve your chance of stomach bleeding.

What special precautions should I follow?

Before taking salsalate,

• tell your medic and pharmacist if you are allergic to salsalate, aspirin, or other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn), any other remedies, or any of the ingredients in salsalate tablets. Ask your apothecary for a list of the ingredients.
• tell your physician and pharmacist what other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal creations you are taking or plan to take. Be certain to note the remedies detailed in the IMPORTANT WARNING section and any of the subsequent: acetazolamide (Diamox); angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), and also perindopril, (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik); antacids; diuretics (”water pills”) such as furosemide (Lasix); lithium (Eskalith, Lithobid);medications for gout such as probenecid (Probalan) and sulfinpyrazone (Anturane); methazolamide; certain oral medications for diabetes such as chlorpropamide (Diabinese), glimepiride (Amaryl, in Avandaryl), glipizide (Glucotrol, in Metaglip), and also glyburide (Diabeta, Glynase, Micronase), tolazamide (Tolinase), and tolbutamide;certain medications for seizures such as phenytoin (Dilantin, Phenytek) and valproic acid (Depakene, Depakote); methotrexate (Trexall); and penicillin (Veetids); salicylates such as bismuth subsalicylate (Kaopectate, Pepto-Bismol), choline magnesium trisalicylatecholine salicylate (Arthropan), diflunisal (Dolobid), and/or magnesium salicylate (Doan’s, others); and also thyroid medications. Your medic may also require you to modify the doses of your medications or monitor you carefully for side effects.
• tell your physician if you have or have ever had any of the circumstances in the IMPORTANT WARNING section or asthma, particularly if you also have frequent stuffed or runny nose or nasal polyps (swelling of the lining of the nose); gout; kidney or liver disease; and/or swelling of the hands, feet, ankles or lower legs.
• you should know that salsalate should not be taken by kids and teenagers who have chicken pox, flu, flu symptoms, or who have obtained the varicella virus (chicken pox) vaccine in the past six weeks because of the risk of Reye’s Syndrome (a serious disorder in which fat builds up on the brain, liver, and other body organs).
• tell your physician if you are pregnant, especially if you are in the last few months of pregnancy; plan to become pregnant; or are breastfeeding. If you evolve expectant while taking salsalate, call your doctor.
• Tell your physician or dentist if you are having surgery, including dental surgery, that you are taking salsalate.

What special dietary instructions should I follow?

Unless your physician advises you otherwise, resume your normal diet.

If I omit a dose, what should I do?

As soon as you notice that you missed a dose, take it. On the other hand, if it is getting close to the time for the next dose, skip the missed one and stick to your usual dosing schedule. If you miss a dose, don’t take twice as much.

What side effects can this medication cause? 

Salsalate may cause side effects. If any of these symptoms are severe or persist, consult your doctor:

• diarrhea
• dizziness

Some side effects can be serious. If you participate in any of the subsequent symptoms or those listed in the IMPORTANT WARNING section, contact your physician immediately:

• ringing in the ears
• loss of hearing
• difficulty breathing or swallowing
• shortness of breath
• hoarseness
• fast heartbeat
• unexplained weight gain
• swelling of the eyes, face, tongue, lips, throat, and also arms, hands, feet, ankles, or lower legs
• rash
• hives
• blisters
• itching
• unusual bleeding or bruising
• pale or cold skin
• fever
• nausea
• headache
• extreme tiredness
• weakness
• lack of energy
• loss of appetite
• pain in the upper good part of the stomach
• yellowing of the skin or eyes
• flu-like symptoms
• cloudy, discolored, or bloody urine
• back pain
• difficult or painful urination

Salsalate may cause other side effects. Contact your physician if you have any unusual problems while taking this medication. If you encounter a serious side effect, you or your physician may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting schedule online. it includes nausea, dizziness, and upset stomach. Advise your physician or pharmacist right away if any of these symptoms persist or worsen. Keep in mind that your physician has given you this medication because he or she believes it will help you more than it will harm you. A lot of individuals who take this medication do not participate any serious side effects.

This drug might raise your pulse. If you notice an increase in your blood pressure, consult your doctor. If you experience any serious side effects, such as heartburn, changes in your hearing (such as ringing in the ears or decreased hearing), easy bruising or bleeding, a fast or pounding heartbeat, signs of infection (such as a fever, sore throat, or fever), kidney problems (such as a change in the amount of urine), or symptoms of heart failure (such as swelling of the ankles and feet, unusual tiredness, unusual or sudden weight gain), you should immediately consult your physician.

Rarely, this medication may result in severe (possibly fatal) liver disease. Move clinical assistance immediately assuming you have any side effects of liver harm, including sickness or regurgitating that doesn’t stop, dim pee, yellowing eyes or skin, loss of hunger, and stomach or stomach torment. It is rare for this drug to induce a severe allergic reaction. However, if you notice any signs of a serious allergic reaction, such as a rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, or difficulty breathing, you should seek medical attention right away.

This is not an exhaustive list of all possible incidental effects. Get in touch with your physician or apothecary if you notice any other effects not listed above. If you live in the United States, ask your doctor about any side effects. You might report aftereffects to FDA. In Canada – Call your PCP. for clinical counsel about aftereffects. You can inform Health Canada of any side effects.

What should I know regarding the storage and disposal of this drug?

Maintain this medication out of the reach of children and in the container it came in. It should be kept at room temperature, missing from moisture and heat (not in the bathroom).

It is important to keep all medicines out of children’s sight and reach because many containers, such as those for eye drops, creams, patches, and inhalers as well as weekly pill minders, are not child-resistant and young children can effortlessly open them. Always lock safety caps and instantly store the medication in a secure location that is up, away, and out of their sight and reach to discourage poisoning in young youngsters.

To prevent pets, children, and others from consuming unneeded medications, special disposal methods should be used. However, you should not discard this medication. Instead, a medicine take-back program is the good option to get rid of your medication. Find out about take-back programs in your area by talking to your pharmacist or contacting your neighborhood recycling or garbage department. See the FDA’s Protected Removal of Medications site for more data if you do not approach a reclaim program.

Precautions

If you are allergic to salsalate, tell your doctor or pharmacist before taking it; or again to anti-inflammatory medicine or different NSAIDs (like ibuprofen, naproxen, celecoxib); or the acid salicylic; or then again if you have some other sensitivities. There is a possibility that this development includes inactive ingredients, which may result in issues such as allergic reactions. For further information, consult your pharmacist.

Inform your doctor or pharmacist of your medical history before taking this medication, especially of: Heart disease (such as a history of a heart attack), high blood pressure, stroke, swelling of the ankles, feet, or hands, blood disorders (such as anemia), bleeding or clotting problems, asthma, aspirin-sensitive asthma (a history of worsening breathing with runny or stuffy nose after enduring aspirin or other nonsteroidal anti-inflammatory drugs), nasal polyps (also known as nasal growths), and individual genetic disorders (such as G-6-PD deficiency and pyruvate kinase deficiency).

Kidney issues can at times happen with the utilization of NSAID meds, including salsalate. If you are dehydrated, have heart failure or kidney disease, are older, or take certain medications (see also the Drug Interactions section), problems are more likely to happen. To avoid becoming dehydrated, follow your doctor’s instructions to drink a lot of fluids, and if your urine volume changes, tell your doctor right away.

Inform your dentist or doctor that you are taking this medication before you have surgery. This medication might make you woozy. Dizziness can also be exacerbated by marijuana (cannabis) or alcohol. Until you are secure to do so, do not move, operate machinery, or engage in any activity requiring alertness. Limit alcoholic drinks. If you are employing marijuana (cannabis), speak to your physician.

This medication might also cause stomach bleeding. Everyday utilization of liquor and tobacco, particularly when joined with this medication, may build your gamble of stomach bleeding. Stop drinking alcohol and smoking. For more information, talk to your pharmacist or medic.

More established grown-ups might be at a more serious gamble for stomach draining and kidney issues. Aspirin and this medication are similar. Kids and teens more youthful than 18 years shouldn’t accept this drug if they have chickenpox, influenza, or any undiscovered disease, or on the other hand assuming that they have quite recently been given a live infection immunization, without first counseling a specialist about Reye’s disorder, an uncommon however difficult sickness.

Let your PCP know if you are expectant or want to evolve pregnant. You should not become pregnant while utilizing this medicine. An unborn child may be harmed by this medication. Assuming you become pregnant, converse with your PCP immediately about the dangers and advantages of this medicine. Due to the possibility of harm to the unborn baby or complications during delivery, you should not take this medication during the final three months of pregnancy.

This medication might pass into bosom milk and could unfortunately affect a nursing baby. Breastfeeding is not suggested while utilizing this medication long haul and in high dosages. Before starting to breastfeed, speak to your physician.

Interactions of salsalate drug

Interactions with other drugs can alter how your medications work or make you more likely to get serious side effects. All probable medicine interactions are not covered in this document. Keep a rundown of the multitude of items you use (counting medicine and nonprescription medications and natural items) and offer it to your primary care physician and drug specialist. Without consulting your Doctor, do not begin, stop, or change the dosage of any medicine.

Aliskiren, ACE inhibitors (like captopril and lisinopril), angiotensin II receptor blockers (like losartan and valsartan), certain medications for seizures (like phenytoin and valproic acid), cidofovir, corticosteroids (like prednisone), dichlorphenamide, medications for gout (like probenecid and sulfinpyrazone), medications that make the urine more acid

When taken with other drugs that can also cause bleeding, this medication may make bleeding more likely. Clopidogrel and other antiplatelet drugs, as well as “blood thinners” like dabigatran, enoxaparin, and warfarin, are for instance. Aspirin, ibuprofen, ketorolac, and naproxen are examples of nonsteroidal anti-inflammatory drugs (NSAIDs) that are similar to this medication and may increase your risk of side effects if taken together. Be sure to carefully read the labels of all prescription and nonprescription medications. Low-portion headache medicine ought to be proceeded whenever recommended by your PCP for explicit clinical reasons, for example, cardiovascular failure or stroke counteraction (typically 81 to 162 milligrams per day). For more details, speak to your pharmacist or medic.

This medication may cause false test results by interfering with certain laboratory tests, such as certain glucose levels in urine and thyroid hormone levels. Make sure doctors know that you take this medication. If you do not have access to a take-back program, visit the website for additional information.

Salsalate dosing information

Usual Adult Dose for Osteoarthritis:

3000 mg orally per day in 2 or 3 disunited doses

Comments:

• Lower doses may be essential to achieve therapeutic blood concentration and to avoid more common side effects (e.g., auditory effects).
• The relief of symptoms comes gradually, and it may take three to four days before the full effect is felt.

Uses: for the treatment of osteoarthritis, rheumatoid arthritis, and other rheumatic diseases that are related

Usual Adult Dose for Rheumatoid Arthritis:

3000 mg taken orally twice or three times daily

Comments:

• To avoid more common side effects (such as auditory effects), lower doses may be required to achieve therapeutic blood concentration.
• The relief of symptoms comes gradually, and it may take three to four days before the full effect is felt.

Uses: for the treatment of osteoarthritis, rheumatoid arthritis, and other rheumatic diseases that are related

In case of an emergency

In case of overdose, contact the poison management helpline at 1-800-222-1222. Information is also available online. If the victim has collapsed, had a seizure, has a problem breathing, or can’t be revived, immediately contact emergency services at 911.

Symptoms of overdose may include:

• ringing in the ears
• dizziness
• headache
• confusion
• extreme tiredness
• sweating
• rapid breathing
• extreme thirst
• muscle cramps
• fainting
• flushing
• loss of consciousness

What other information should I know?

Inform your doctor and the laboratory staff that you are taking salsalate before any tests. Do not give your medication to anyone else. If you have any questions about refilling your medicine, ask your apothecary. You are required to keep a written record of all of your prescription and nonprescription (over-the-counter) medications, as well as any supplements, vitamins, or other dietary supplements, that you are taking. When you visit a doctor or are admitted to a hospital, you should bring this list with you. It is likewise significant data to convey to you if there should arise an occurrence of crises.

Overdose of salsalate drug

Call 911 if someone has gone too far and experiences serious side effects like difficulty breathing or falling. Immediately contact a poison control center. Poison control focuses in the US can be reached at 1-800-222-1222. A commonplace toxin control focus can be reached by the inhabitants of Canada. Some of the signs of an overdose include: seizures, confusion, ringing in the ears, vomiting, diarrhea, dizziness, rapid breathing, and other symptoms

Notes

Try not to impart this drug to other individuals. While you are taking this medication, you may have your blood pressure, complete blood count, liver or kidney function, and salicylic acid levels tested by a lab or doctor. Keep all clinical and lab arrangements. For more information, consult your physician.

If you have arthritis, making changes to your lifestyle, like losing weight if you need to and doing strengthening and conditioning exercises, may help you be more flexible and make your joints work better. For specific instructions, consult your physician.

Missed Dose: If you take this drug regularly (not “as required”) and ignore taking a dose, take it as soon as you remember. Forget the missed dose if it is close to the next dose. Take your next dose when you normally want. To hook up, do not crease the dose.

Storage

Store at room temperature out from light and/or dampness. Keep it out of the bathroom. Keep drugs out of pets and children.

Unless required otherwise, do not pour drugs down a drain or flush them down the toilet. Properly dispose of this item when it is terminated or presently not needed. Confer your pharmacist or the waste management corporation in your area.

Important Warning

Individuals who take nonsteroidal anti-inflammatory medications (NSAIDs) (other than aspirin) such as salsalate may have a higher risk of having a heart attack or a stroke than individuals who do not take these medications. These circumstances may happen without warning and may cause death. This chance may be higher for people who take NSAIDs for a long time. Inform your physician if you or anyone in your family has or has ever had heart disease, heart failure, a heart attack, or a stroke; if you smoke; and if you have or have ever had high cholesterol, elevated blood pressure, or diabetes. Get trouble medical help right away if you experience any of the subsequent symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech. If you are going to have a coronary artery bypass graft (CABG); a type of heart surgery), salsalate should not be taken before or after the procedure.

The stomach or intestine may develop ulcers, bleeding, or holes from NSAIDs like salsalate. These issues can arise at any time during treatment, occur without showing any symptoms, and may result in death. The gamble might be higher for individuals who take NSAIDs for quite a while, are more seasoned, have chronic weakness, smoke, or drink a lot of liquor while taking salsalate. Let your primary care physician know if you take any of the accompanying meds: anticoagulants (‘blood thinners’) like warfarin (Coumadin); aspirin; different NSAIDs like ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); or oral steroids like prednisone (Deltasone), methylprednisolone (Medrol), and dexamethasone (Decadron, Dexone). Also, tell your doctor if you’ve ever had an ulcer, stomach or intestine bleeding, or any other bleeding disorder. Assuming you experience any of the accompanying side effects, quit accepting salsalate and call your primary care physician: stomach pain, heartburn, vomiting something that looks like blood or coffee grounds, blood in the stool, or stools that are black and tarry

Keep all of your lab and doctor’s appointments. Your doctor will keep a close eye on your symptoms and probably order some tests to see how your body reacts to salsalate. Make sure to tell your doctor how you’re feeling so he or she can give you the right amount of medication to treat your condition with the least amount of serious side effects possible.

Your doctor or pharmacist will give you the manufacturer’s patient information sheet (Medication Guide) when you begin treatment with salsalate each time you refill your prescription. Read the details carefully and ask your physician and/or pharmacist if you have any inquiries. You can also visit the Food and Drug Administration (FDA) website and the manufacturer’s website to obtain the Medication Guide.

FAQ