Flurbiprofen

Description

Flurbiprofen is a nonsteroidal anti-inflammatory drug in the phenylalkanoic acid derivative class. It is mostly used as an anti-miotic before surgery, but it can also be taken orally to treat arthritis or pain in the teeth. Ibuprofen-like side effects are also present. Flurbiprofen is a nonsteroidal anti-inflammatory drug (NSAID) in the phenylalkanoic acid derivative class. In an ophthalmic solution, it is mostly used as a pre-operative anti-miotic, but it can also be taken orally to treat dental or arthritis pain. Ibuprofen-like side effects are also present.

During the 1960s, Boots UK’s research department discovered propionic acid, which led to the discovery of ibuprofen, indomethacin, diclofenac, naproxen, ketoprofen, and sulindac.

• Formula: C15H13FO2
• Generic Name – Flurbiprofen
• CASE ID: 5104-49-4
• Other names: (±)-2-fluoro-α-methyl-(1,1′-biphenyl)-4-acetic acid
• Metabolism: Liver (CYP2C9)
• Pregnancy category: AU: B2
• AHFS/Drugs.com: Monograph
• Type – Small Molecule
• Groups – Approved, Investigational
• Chemical Formula – C15H13FO2

Synonyms

• Flurbiprofen
• Flurbiprofene
• Flurbiprofeno
• Flurbiprofenum

Associated Conditions

• Ankylosing Spondylitis (AS)
• Back Pain, Acute
• Chronic Back Pain
• Menstrual Distress (Dysmenorrhea)
• Muscle Spasms
• Non-Articular Rheumatic Muscle Spasms
• Osteoarthritis (OA)
• Pain
• Pain, Inflammatory
• Post Traumatic Pain
• Postoperative pain
• Rheumatoid Arthritis
• Spinal pain

Background

An analgesic and antipyretic, flurbiprofen drug, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA). Symptomatic treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis can be achieved with oral flurbiprofen formulations. To prevent or reduce intraoperative miosis, flurbiprofen can also be applied topically before ocular surgery. Flurbiprofen is fundamentally and pharmacologically connected with fenoprofen, ibuprofen, and ketoprofen.

Why is this medication prescribed?

Flurbiprofen is used to treat osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints) pain, tenderness, swelling, and stiffness. Flurbiprofen belongs to the NSAIDs class of drugs. It works by preventing the body from creating a substance that induces inflammation, pain, and fever.

Pharmacodynamics

Flurbiprofen is a propionic acid-based nonsteroidal anti-inflammatory agent (NSAIA) with similar pharmacological effects to those of other prototypica NSAIAs and structurally and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen. Flurbiprofen has antipyretic, analgesic, and anti-inflammatory properties. Flurbiprofen, which is sold in stores, is a racemic mixture of (+)S- and (-)R-enantiomers. The S-enantiomer seems to have a large portion of the calming, while the two enantiomers might have pain-relieving movement.

Mechanism of action

Similar to other NSAIAs, flurbiprofen inhibits cyclooxygenase (COX), the enzyme that converts arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2) in the prostaglandin synthesis pathway, resulting in an anti-inflammatory effect. This effectively reduces the concentration of prostaglandins that cause pain, swelling, fever, and inflammation. Flurbiprofen is a non-selective COX inhibitor that reduces both COX-1 and COX-2 activity. Prostaglandin inhibitory activity makes it one of the most effective NSAIDs.

Absorption

After being taken orally, fluribiprofen is rapidly and almost completely absorbed. After oral administration, plasma concentrations reach their highest point 0.5 to 4 hours later.

Volume of distribution

• 14 L [Normal Healthy Adults]
• 12 L [Geriatric Arthritis Patients]
• 10 L [End-Stage Renal Disease Patients]
• 14 L [Alcoholic Cirrhosis Patients]
• 0.12 L/kg

Protein binding

> 99 percent bound, mostly to albumin. Ties to an alternate essential restricting site on egg whites than anticoagulants, sulfonamides, and phenytoin. Hepatic metabolism Flurbiprofen is metabolized into its primary metabolite, 4′-hydroxy-flurbiprofen, by cytochrome P450 2C9. In animal models of inflammation, the 4′-hydroxy-flurbiprofen metabolite lacked significant anti-inflammatory activity.

To see their reaction partners, hover over the outcomes below.

• Flurbiprofen
  • 4′-Hydroxyflurbiprofen
  • Flurbiprofen glucuronide

Route of elimination

The excretion of flurbiprofen into human milk is low. Under 3% of flurbiprofen is discharged unaltered in the pee following a portion, with roughly 70% of the portion disposed of as parent medication and metabolites. Flurbiprofen metabolites are primarily eliminated through renal elimination.

Half-life – R-flurbiprofen has a half-life of 4.7 hours; S-flurbiprofen, 5.7 hours

Clearance – Not Available

Food Interactions

• Avoid alcohol.
• Take it with food. Food reduces irritation.

Toxicity of flurbiprofen

LD50=10 mg/kg (orally in dogs).

In some patients, selective COX-2 inhibitors have been linked to an increased risk of serious cardiovascular events such as myocardial infarction and stroke. To determine flurbiprofen’s cardiovascular risk, the available data are insufficient. Flurbiprofen may cause fluid retention and edema as well as an increase in blood pressure. Be cautious in patients with heart failure or fluid retention. hazard of GI toxicity, including perforation, bleeding, and ulceration. Hazard of direct renal injury, including renal papillary corruption. Exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis are examples of potentially fatal skin reactions. Some of the more common adverse reactions include abdominal pain, constipation, diarrhea, dyspepsia, flatulence, GI bleeding, GI perforation, nausea, peptic ulcer, vomiting, renal function abnormalities, anemia, dizziness, edema, liver function test abnormalities, headache, prolonged bleeding time, pruritus, rash, and tinnitus. Oral propionic acid derivatives have been linked to a relatively high frequency of allergic reactions, even though this association has only been occasionally documented with flurbiprofen.

How to use Flurbiprofen

Peruse the Drug Guide given by your drug specialist before you begin taking flurbiprofen and each time you get a top-off. In the off circumstance that you have any queries, ask your PCP or drug specialist. As directed by your doctor, take this medication by mouth two to four times per day. Unless your doctor tells you otherwise, take this medication with a full glass of water (8 ounces, or 240 milliliters). Avoid lying down for at least ten minutes after taking this medication. Take this drug with food, milk, and/or an antacid if you experience stomach upset while taking it.

Your medical disorder and response to treatment determine the dosage. To lessen your chance of stomach bleeding and other side effects, take this medication at the most subordinate effective dose for as small a time as feasible. Do not take this medication at a higher dose or for a longer period than prescribed. Keep taking this medication as prescribed for ongoing conditions like arthritis. Talk to your medic or pharmacist about the benefits and dangers.

For some conditions, like arthritis, regular use of this medication may take up to two weeks before you see full results. Keep in mind that painkillers are most effective when taken as soon as the first signs of pain arise if you are taking this medication “as needed” rather than regularly. The medication may not be as effective if you wait until the pain has gotten worse.

If your disease gets worse, tell your medic.

Uses – Additionally, see the Warning section. Flurbiprofen is used to ease arthritis pain, swelling, and stiffness in the joints. Additionally, it is used to relieve dental pain, cramps during menstruation, and muscle pains. A nonsteroidal anti-inflammatory drug (NSAID) is flurbiprofen. It works by hindering your body’s development of specific normal substances that cause aggravation. This influence assists with diminishing enlarging and suffering. In the occasion that you are treating a constant condition like joint pain, get some information about non-drug medicines or potentially utilize different prescriptions to treat your aggravation.

IMPORTANT WARNING

Other than aspirin, people who take nonsteroidal anti-inflammatory drugs (NSAIDs) like flurbiprofen may be more likely to have a heart attack or stroke than people who don’t. These things can also happen without warning and could induce death. This could be more likely to happen to individuals who take NSAIDs for a prolonged time. If you have recently experienced a heart attack, you should not take an NSAID like flurbiprofen unless your doctor tells you to. If you smoke, tell your primary care physician if you or anyone in your family has ever had coronary disease, respiratory failure, stroke, or diabetes, as well as if you have ever had high cholesterol, hypertension, or diabetes. You should seek emergency medical care right away if you notice any of the following symptoms: Symptoms include chest pain, trouble breathing, weakness in one side or part of the body, and slurred speech. If you are going to have a coronary artery bypass graft (CABG; a kind of heart surgery), you shouldn’t take flurbiprofen before or after the procedure.

NSAIDs like flurbiprofen can cause ulcers, bleeding, or holes in the stomach or intestines. These problems may also emerge whenever during treatment, happen without showing any side effects, and may bring about death. If you take NSAIDs for a long time, are older, suffer from chronic weakness, or consume a lot of alcohol while taking flurbiprofen, the risk may be higher. Inform your medic if you take any of the subsequent medications. “blood thinners,” or anticoagulants like warfarin (Coumadin, Jantoven); aspirin; other NSAIDs like ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); oral steroids like prednisone (Rayos), methylprednisolone (Medrol), and dexamethasone citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft) are instance of selective serotonin reuptake inhibitors (SSRIs). serotonin-norepinephrine reuptake inhibitors (SNRIs) like duloxetine (Cymbalta), desvenlafaxine (Khedezla, Pristiq), and also venlafaxine (Effexor XR). Also, tell your medic if you have ever had ulcers, stomach or intestine bleeding, or any other bleeding disorder. Stop taking flurbiprofen and contact your doctor if you experience any of the following symptoms: stomach pain, heartburn, bloody or tarry stools, blood in the stool, or vomit that looks like coffee grounds

Keep all of your lab and doctor’s appointments. Your symptoms will be closely monitored by your doctor, who may also order specific tests to assess your body’s response to flurbiprofen. Be sure to let your medic know how you’re feeling so that he or she can specify the right amount of medication to treat your condition with the fewest possible serious side effects.

When you begin treatment with flurbiprofen and each time you refill your prescription, your doctor or pharmacist will provide you with the manufacturer’s patient information sheet (Medication Guide). If you have any queries, make sure to consult your physician or pharmacist. The Medication Guide can also be obtained by visiting the websites of the manufacturer or the Food and Drug Administration (FDA).

Precautions

Before taking flurbiprofen,

• If you have an allergy to flurbiprofen, aspirin, other NSAIDs like ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), or any of the ingredients in flurbiprofen tablets, tell your doctor and pharmacist. For a list of the ingredients, ask your medic or pharmacist.
• tell your medic and drug specialist what solution and nonprescription prescriptions, nutrients, nourishing enhancements, and natural items you are taking or plan to take. Be sure to mention any of the following, in accumulation to the medications recorded in the Important Warning section: benazepril (in Lotrel), captopril (in Vaseretic), enalapril (in Vaseretic), fosinopril (in Zestoretic), lisinopril (in Zestoretic), moexipril (in Univasc), perindopril (in Prestalia), quinapril (in Accutril), ramipril (in Altace), and trandolapril ( Angiotensin receptor blockers (ARBs) such as telmisartan (Micardis, in Micardis HCT, in Twynsta), valsartan (in Exforge HCT), and also eprosartan (Teveten), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, in Benicar beta blockers like atenolol (Tenormin, also known as Tenoretic), labetalol (Trandate), metoprolol (Lopressor, Toprol XL, or Dutoprol), nadolol (Corgard, also known as Corzide), and propranolol (Hemangeol, Inderal, and Innopran); diuretics, or “water pills” lithium, or a Lithobid; and methotrexate, including Otrexup, Rasuvo, and Trexall Your doctor might have to adjust the amount of your medication or keep a closer eye on you for side effects.
• If you have asthma or have ever had it, tell your doctor, especially if you also frequently have a stuffy or runny nose or nasal polyps, which are bumps in the lining of the nose; heart disease; hands, feet, ankles, or lower legs swelling; or illness of the kidneys or liver.
• If you are breastfeeding or intend to evolve pregnant, tell your doctor. If taken at least 20 weeks into a pregnancy, flurbiprofen can harm the fetus and cause problems during delivery. Unless your doctor tells you to, you should not take flurbiprofen before or after you reach 20 weeks of pregnancy. Call your medic if you become pregnant while taking flurbiprofen.
• Inform the dentist or doctor that you are taking flurbiprofen if you are having surgery, including dental surgery.

If you are allergic to flurbiprofen, tell your doctor or pharmacist before taking it; aspirin or other nonsteroidal anti-inflammatory drugs (like ibuprofen, naproxen, or celecoxib); or if you are allergic to anything else. There is a chance that this product includes inactive ingredients, which may result in issues such as allergic reactions. For further information, consult your pharmacist.

Inform your doctor or pharmacist of your medical history before taking this medication, especially of: asthma, aspirin-sensitive asthma (a history of worsening breathing and a runny or stuffy nose after taking aspirin or other NSAIDs), bleeding and clotting issues, blood disorders like anemia, diabetes, growths in the nose (nasal polyps), heart disease (like a heart attack), high blood pressure, liver disease, stroke, swelling (edema, fluid retention), and issues with the stomach, intestines, and esophagus. Flurbiprofen and other nonsteroidal anti-inflammatory drugs (NSAIDs) can occasionally cause kidney problems. If you are dehydrated, have heart failure or kidney disease, are older, or take certain medications, problems are more likely to happen (see also the Drug Interactions section). Follow your doctor’s orders to drink a lot of fluids to avoid becoming dehydrated, and tell your doctor right away if you have pink or bloody urine or if the quantity of urine changes in an unusual way.

You might evolve drowsy and/or dizzy from this drug. Liquor or weed (marijuana) can make you more discombobulated or sleepy. Until it is safe to do so, do not drive, operate machinery, or engage in any activity that requires you to be alert. Consume only non-alcoholic drinks. Consult your doctor if you are using marijuana (cannabis). This medication may also induce bleeding in the stomach. Consuming alcohol and tobacco on an everyday basis, specifically when taking this drug, may raise your risk of stomach bleeding. Stop drinking alcohol and smoking. Find out from your pharmacist or doctor how much alcohol you can drink safely.

You might evolve more prone to sunburn from taking this medicine. Reduce your time spent in the sun. Avoid sunlamps and tanning booths. When you are outside, involve sunscreen and wear protective gear. If you get sunburned and/or have skin blisters or redness, tell your medic right away. Before having a medical procedure, inform your primary care physician or dental specialist regarding every one of the items you use (counting doctor-prescribed drugs, nonprescription medications, and natural items). When taking this medication, older individuals may be more likely to have stomach or intestinal bleeding, kidney issues, a heart attack, or a stroke.

Discuss the advantages and dangers of this medication with your doctor(s) if you are a female of childbearing age. Inform your medic if you are pregnant or planning to become pregnant. This drug has the potential to induce harm to an unborn child and disrupt normal labor and delivery. Between the years of 20 and delivery, it should not be used during gestation. If your medic decides that you need to take this medication between 20 and 30 weeks of pregnancy, you should take the lowest effective dose for as small time as possible. This medication should not be used after 30 weeks of gestation. This medication is in breast milk. Talk to your medic before starting a breastfeeding program.

What special dietary instructions should I follow?

Unless your physician tells you otherwise, restart your normal diet.

If I skip a dose, what should I do?

When you remember, take the dose you missed. On the other hand, if the time for the next dose is getting close, skip the missed one and stick to your usual routine. Do not take two quantities to make up for a missed dose.

What should I know about the medicine’s storage and disposal?

Keep this drug away and out of the reach of children and in the original container. It should be kept at room temperature, away from excessive intensity, and not in the bathroom. Because many drug containers, such as those for eye drops, creams, patches, inhalers, and also weekly pill minders, are not child-resistant and young children can also easily open them. To avoid poisoning young children, lock all safety caps and immediately store the medication in a secure location that is away from them, out of their sight, and out of their reach.

To prevent pets, children, and others from ingesting unnecessary medications, special disposal methods should be used. On the other hand, you shouldn’t toss this medication out. Instead, the best way to get rid of your medication is through a program called a “medicine take-back.” Figure out nearly your local’s reclaim plans by talking with your drug specialist or the division of Trash and reusing in your space.

What other information should I know?

Keep your medication away from anyone else. Ask your apothecary any questions you might have about refilling your prescription. Each of your enhancements, nutrients, and other dietary enhancements, as well as the entirety of your medicine and nonprescription (non-prescription) drugs, should be archived in compose. When you visit the hospital or doctor, you should always bring this list. In the event of an emergency, it is essential to have this information readily available.

What side effects can this medication cause?

There may be side effects from flurbiprofen. Consult your doctor if any of these symptoms persist or become severe:

• headache
• nervousness or anxiety
• depression
• memory problems
• shaking of an uncontrollable movement of the part of the body
• difficulty falling asleep or staying asleep
• vomiting
• gas
• constipation
• diarrhea
• runny nose
• ringing in the ears

Some side effects can be serious. Call your medic right away if you encounter any of the symptoms listed below or in the Important Warning section. Take no more flurbiprofen until you address your PCP.

• changes in vision (blurriness, difficulty seeing)
• unexplained weight gain
• shortness of breath or difficulty breathing
• swelling in the abdomen, ankles, feet, and/or legs
• fever
• blisters
• rash
• itching
• hives
• swelling of the eyes, face, lips, tongue, throat, and also hands
• difficulty breathing or swallowing
• pale skin
• fast heartbeat
• excessive tiredness
• unusual bleeding or bruising
• lack of energy
• nausea
• loss of appetite
• upper right part of the stomach pain
• flu-like symptoms
• yellowing of the skin or eyes
• cloudy, discolored, or bloody urine
• back pain
• difficult or painful urination

Flurbiprofen may cause other side effects. Consult your doctor if you experience any unusual side effects while taking this medication.

You or your doctor can contact the FDA’s MedWatch Adverse Event Reporting program online or by phone at 1-800-332-1088 to report a serious side effect.

Flurbiprofen dosing information

Usual Adult Dose for Osteoarthritis:

• Orally, 200 to 300 mg in 2 to 4 divided doses daily. The maximum amount taken in a single dose is: 100 mg
• Remarks – When the reaction to not entirely settled, portion and recurrence ought to be changed following the most reduced compelling portion for the briefest length conceivable to suit individual patient treatment objectives.
• Uses – for the treatment of osteoarthritis and rheumatoid arthritis symptoms

Usual Adult Dose for Rheumatoid Arthritis:

• Orally, 200 to 300 mg in 2 to 4 divided doses daily. The maximum amount taken in a single dose is: 100 mg
• Remarks – To meet the specific treatment objectives of each patient, dose, and frequency should be adjusted to the lowest effective dose for the shortest amount of time after the response to therapy has been determined.
• Uses – for the treatment of osteoarthritis and rheumatoid arthritis symptoms

Flurbiprofen may interact with other medications

The oral tablet flurbiprofen may interact with other medications, vitamins, or herbs you may be taking. When a substance alters the way a drug works, this is called an interaction. This may be harmful or hinder the drug’s effectiveness. Your PCP ought to painstakingly deal with each of your drugs to assist with forestalling associations. Inform your doctor of any vitamins, supplements, or other medications you take. Discuss the possibility of this medication interfering with any other medications you are taking with your doctor or pharmacist.

The following is a list of drugs that may interact with flurbiprofen.

Corticosteroids

When you take flurbiprofen with corticosteroids like prednisone or dexamethasone, your risk of stomach ulcers or bleeding can go up.

Cancer drug

Flurbiprofen and pemetrexed can make you more likely to get sick, have problems with your kidneys, or have problems with your stomach.

Heart drug

Digoxin can raise your body’s levels when taken with flurbiprofen. Your doctor may keep an eye on your digoxin levels if you take these medications together.

Transplant drug

Flurbiprofen and cyclosporine can raise cyclosporine levels in the body, which can irritate the kidneys. Your doctor should keep an eye on your kidney function if you take these medications together.

Disease-modifying antirheumatic drug

Flurbiprofen and methotrexate can increase methotrexate levels in the body. Kidney issues and an increased risk of infection may arise as a result.

Anticoagulant/blood thinner

Flurbiprofen and warfarin both raise your risk of stomach bleeding.

Bipolar disorder medication

Flurbiprofen and lithium can increase the amount of lithium in your blood to dangerous levels. Tremors, excessive thirst, and confusion are all signs of lithium toxicity. Your doctor may keep an eye on your lithium levels if you take these medications together.

Blood pressure drugs

Combining these medications with flurbiprofen may lessen their ability to lower blood pressure. Drugs like these are examples: beta-blockers like propranolol and atenolol are angiotensin-converting enzyme (ACE) inhibitors. Examples of these include benazepril and captopril.

Diuretics (water pills)

When flurbiprofen is combined with certain diuretics, their effects may be diminished. These diuretics include the following:

• hydrochlorothiazide
• furosemide

Nonsteroidal anti-inflammatory drugs (NSAIDs)

Flurbiprofen is a NSAID. It may increase your risk of side effects like stomach bleeding or ulcers if you take it with other NSAIDs. Some examples of NSAIDs are:

• aspirin
• ibuprofen
• naproxen
• etodolac
• diclofenac
• fenoprofen
• ketoprofen
• tolmetin
• indomethacin
• meloxicam

Disclaimer: Our objective is to offer you the most current and pertinent information. However, we cannot guarantee that this information covers all possible interactions because drug interactions vary from person to person. Do not rely solely on this information for medical advice. Make sure you talk to your doctor about any potential interactions you might have with any prescription, over-the-counter, or vitamins, herbs, or supplements you’re taking.

Interactions – Interactions with other drugs can also alter the way your medications work or make you more possible to get serious side effects. All possible medicine interactions are not covered in this document. Share a list with your medic and pharmacist of all the products you use, both prescription and nonprescription, as well as herbal products. Without conferring with your physician, do not begin, stop, or alter the dosage of any drug.

Some products that may interact with this medication include aliskiren, ACE inhibitors (such as captopril and lisinopril), angiotensin II receptor blockers (such as losartan and valsartan), cidofovir, corticosteroids (such as dexamethasone and prednisone), lithium, methotrexate, and “water pills” (such as diuretics like furosemide).

When taken with other prescriptions that can also induce bleeding, this medication may make bleeding more likely. Antiplatelet medications like clopidogrel and “blood thinners” like dabigatran, enoxaparin, and warfarin are two illustrations. Aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, ketorolac, and naproxen, among others, are expected pain relievers and fever reducers on prescription and nonprescription medicines. If you take these and flurbiprofen together, you might experience more side effects. However, unless your medic tells you otherwise, you should continue taking aspirin if your medic has prescribed a low dose (typically 81-162 milligrams per day) to stop heart attack or stroke. For more details, talk to your pharmacist or doctor.

Overdose

Contact 911 instantly if a person has taken an excessive amount of medication and is undergoing serious symptoms such as unconsciousness or difficulty breathing. Otherwise, immediately contact a poison control center. In the United States, poison control centers can also be reached at 1-800-222-1222. Canadians can get in touch with a provincial poison management center. Extreme drowsiness, loss of consciousness, severe stomach pain, and slow or shallow breathing are all signs of an overdose.

Notes – Do not give this medicine to anyone else. While you are taking this medication, you may have your blood pressure, liver and kidney function, and complete blood counts were taken. Keep away from all lab and medical appointments. For more information, consult your physician. Alterations to your lifestyle, including, if necessary, weight loss and strengthening and conditioning exercises, may assist in enhancing your flexibility and joint function. For specific instructions, consult your physician.

Missed Dose – If you take this drug regularly (not just “as needed”) and forget to take a dose, take it as soon as you remember. Skip the missed quantity if it is close to the next dose. When you normally would, take your following dose. To detect up, do not double the dose.

Storage – Maintain the product at room temperature in a tightly sealed container out of direct sunlight and moisture. Keep it out of the bathroom. Keep drugs away from pets and children. Unless mandated otherwise, do not pour drugs down a drain or flush them down the toilet. When this consequence has expired or is no extended required, properly dispose of it. Consult your pharmacist or the waste management company in your area.

In case of an emergency/overdose

Contact the poison management helpline at 1-800-222-1222 for the possibility of an overdose. Online resources are also available. Call 911 right away if the victim has tumbled, had a seizure, is having problems in breathing, or cannot be awakened.

Symptoms of overdose may include:

• lack of energy
• drowsiness
• nausea
• vomiting
• stomach pain
• bloody, black, or tarry stools
• vomit that is bloody and/or looks like coffee lands
• difficulty in breathing
• coma (loss of consciousness for some time)

Flurbiprofen warnings

This drug comes with several signs.

Allergy warning

Flurbiprofen can provoke a severe allergic reaction. Symptoms can include:

• trouble breathing
• swelling of your throat or tongue
• hives

If you develop these symptoms, contact 911 or go to the nearest emergency room. Do not take this drug again if you have ever had an allergic response to it. Taking it again could be disastrous (cause death).

Alcohol and smoking warning

Consuming alcohol while taking flurbiprofen can cause stomach irritation. This can result in ulcers or fatal bleeding from the stomach or intestines. Smoking also makes you more likely to get these problems. Inform your doctor if you smoke cigarettes or consume more than three alcoholic drinks per day before starting this medication.

Warnings for people with certain health conditions

• Those who suffer from heart disease: You should not take flurbiprofen if you have or are at risk of heart disease. It could make you more likely to have a heart attack, stroke, or blood clot.
• For individuals with heart failure or high blood pressure: Flurbiprofen has the potential to either exacerbate or cause high blood pressure. Flurbiprofen may also make heart failure worse by making swelling and fluid retention worse. If you are taking flurbiprofen and have high blood pressure or heart failure, your doctor may closely monitor you.
• For individuals with stomach issues: If you have a history of ulcers or stomach bleeding, this medication increases your risk.
• for kidney disease sufferers: Flurbiprofen may not be eliminated as efficiently as it should by your body. The medication may build up in your body as a result, which could result in additional side effects.

Warnings for other groups

• for expecting mothers: Flurbiprofen in pregnant women has not been the subject of any research. However, it has been demonstrated that taking flurbiprofen during the third trimester of pregnancy raises the fetus’s risk of developing a heart condition. As a result, use should be avoided during pregnancy beginning at 30 weeks.
• If you are expectant or plan to evolve pregnant, tell your medic.
• for breastfeeding mothers: Breast milk has been shown to contain flurbiprofen. If a child is breastfed, this could have side effects. If you’re breastfeeding, tell your doctor. You might have to decide whether to stop taking flurbiprofen or stop breastfeeding.
• Senior adults: When taking this medication, people 65 and older are more likely to suffer from stomach problems and kidney failure. Your doctor may alter your dosage if you are over 65 years old.
• For youngsters: Flurbiprofen’s effectiveness and safety in children under the age of 18 have not been established.

Important considerations for taking flurbiprofen

If your doctor prescribes flurbiprofen, keep these points in mind.

General

• Take flurbiprofen with meals and a glass of water. This can assist with bringing down your gamble of getting a bombshell stomach or an ulcer.
• Take your portion at ordinary spans. For example, on the off chance that your primary care physician recommends flurbiprofen three times each day, dismantle each portion for eight hours.
• Try not to cut or pulverize the tablet.

Storage

• Store flurbiprofen at room temperature somewhere in the range of 68°F and 77°F (20°C and 25°C).
• Try not to store this drug in soggy or sodden regions, like restrooms.

Refills

The prescription for this medication can be renewed. A new prescription should not be required to refill this medication. Your doctor will write the number of permitted refills on your prescription.

Travel

When you are on vacation and taking your medication:

• Always be close to your medications. Never put it in a realistic look at the pack while flying. It ought to be stored in your carry-on bag.
• Don’t be concerned about the airport’s X-ray machines. They will not harm your medication.
• It is conceivable that the airport staff will ask you to show them your medication label. Always bring the original prescription-labeled container with you.
• This medication should not be left in your car or the glove compartment. This should not be done when it is very hot or very cold.

Clinical monitoring

If you take flurbiprofen for a long time, your doctor might do a blood test to see if there are any signs of bleeding. They might also keep an eye on you to look for signs of stomach or intestine bleeding or ulcers. In addition, they may observe your blood tension.

FAQ